Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 12/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12496138 | 0.92 | GRM4 (0.45) | GRM4HPGDKDM4ESIRT1SMN1; SMN2 | |
| SCHEMBL21313228 | 0.87 | TLR8 (0.46) | ADORA2AGRM4KDM4ENPSR1SMN1; SMN2 | |
| SCHEMBL21313152 | 0.87 | ADORA2A (0.51) | ADORA2AHPGDKDM4ENPSR1SMN1; SMN2 | |
| SCHEMBL21313180 | 0.84 | ADORA2A (0.45) | ADORA2AGRM4HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL21313154 | 0.84 | ADORA2A (0.46) | ADORA2AGRM4HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL12495884 | 0.84 | HDAC3 (0.41) | GRM4HPGDKDM4ESIRT1SMN1; SMN2 | |
| SCHEMBL21313237 | 0.83 | ADORA2A (0.42) | ADORA2AGRM4HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL12495836 | 0.83 | ADORA2A (0.55) | ADORA2AHPGDKDM4ENPSR1SMN1; SMN2 | |
| SCHEMBL21313249 | 0.82 | GRM4 (0.45) | ADORA2AGRM4KDM4ESMN1; SMN2ADORA1 | |
| SCHEMBL21313195 | 0.82 | DHFR (0.38) | GRM4HPGDKDM4ESMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3195867-B1 | PYRIMIDINE COMPOUNDS INHIBITING THE FORMATION OF NITRIC OXIDE AND PROSTAGLANDIN E2, METHOD OF PRODUCTION THEREOF AND USE THEREOF | USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CR V V I (CZ) | 2019-09-04 | — | — | EP | claimed |