Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12496138 | 0.95 | GRM4 (0.45) | TLR8GRM4MAPTNPC1RAB9A | |
| SCHEMBL21313154 | 0.92 | ADORA2A (0.46) | TLR8DHFRGRM4MAPTNPC1 | |
| SCHEMBL21313237 | 0.91 | ADORA2A (0.42) | TLR8GRM4MAPTNPC1RAB9A | |
| SCHEMBL21313184 | 0.89 | HRH2 (0.49) | MAPTADORA2ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL21313269 | 0.89 | ADORA2A (0.40) | TLR8DHFRGRM4MAPTNPC1 | |
| SCHEMBL21313180 | 0.88 | ADORA2A (0.45) | TLR8GRM4MAPTNPC1RAB9A | |
| SCHEMBL21313196 | 0.87 | ADORA2A (0.44) | GRM4MAPTNPC1RAB9AADORA2A | |
| SCHEMBL12495884 | 0.87 | HDAC3 (0.41) | TLR8GRM4MAPTNPC1RAB9A | |
| SCHEMBL16223029 | 0.87 | MAOB (0.41) | TLR8GRM4MAPTNPC1RAB9A | |
| SCHEMBL21313195 | 0.85 | DHFR (0.38) | TLR8DHFRGRM4MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3195867-B1 | PYRIMIDINE COMPOUNDS INHIBITING THE FORMATION OF NITRIC OXIDE AND PROSTAGLANDIN E2, METHOD OF PRODUCTION THEREOF AND USE THEREOF | USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CR V V I (CZ) | 2019-09-04 | — | — | EP | claimed |