Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.37 |
| ▸ | ATXN2 | Q99700 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.34 |
| ▸ | GPR183 | P32249 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16963158 | 1.00 | HRH3 (0.40) | HRH3CCR2MAPTALDH1A1ENPP2 | |
| SCHEMBL16962973 | 0.89 | CCR2 (0.40) | HRH3CCR2MAPTALDH1A1ENPP2 | |
| SCHEMBL21313885 | 0.89 | CCR2 (0.40) | HRH3CCR2MAPTALDH1A1ENPP2 | |
| SCHEMBL16963747 | 0.87 | ENPP2 (0.40) | HRH3CCR2MAPTALDH1A1ENPP2 | |
| SCHEMBL21313879 | 0.87 | ENPP2 (0.40) | HRH3CCR2MAPTALDH1A1ENPP2 | |
| SCHEMBL21313827 | 0.87 | ENPP2 (0.40) | HRH3CCR2MAPTALDH1A1ENPP2 | |
| SCHEMBL16961684 | 0.87 | ENPP2 (0.40) | HRH3CCR2MAPTALDH1A1ENPP2 | |
| SCHEMBL21323305 | 0.85 | CCR2 (0.42) | HRH3CCR2MAPTALDH1A1ENPP2 | |
| SCHEMBL16963160 | 0.85 | CCR2 (0.42) | HRH3CCR2MAPTALDH1A1ENPP2 | |
| SCHEMBL16963155 | 0.85 | CCR2 (0.42) | HRH3CCR2MAPTALDH1A1ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900669-B1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND RELATED COMPOUNDS AS AUTOTAXIN (ATX) INHIBITORS AND AS INHIBITORS OF THE LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION FOR TREATING E.G. RENAL DISEASES | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |