Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | TOP2A | P11388 | 2/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21319054 | 0.90 | ADORA3 (0.43) | ADORA3ADORA1KDM4ETLR7KMT2A | |
| SCHEMBL19945665 | 0.88 | ABCB1 (0.38) | ADORA3ADORA1KMT2ACTSB | |
| SCHEMBL21318986 | 0.84 | ADORA3 (0.31) | ADORA3ADORA1KDM4EKMT2AMEN1 | |
| SCHEMBL19945779 | 0.83 | MEN1 (0.36) | KDM4EKMT2AMEN1LMNA | |
| SCHEMBL21318984 | 0.82 | KMT2A (0.34) | ADORA3KMT2AMEN1LMNA | |
| SCHEMBL21318963 | 0.82 | TSHR (0.31) | — | |
| SCHEMBL19945526 | 0.82 | ADORA3 (0.36) | ADORA3ADORA1KDM4EKMT2AMEN1 | |
| SCHEMBL23772953 | 0.80 | SMN1; SMN2 (0.37) | ADORA3ADORA1TLR7KMT2ALMNA | |
| SCHEMBL21319005 | 0.80 | TLR7 (0.31) | TLR7KMT2AMEN1LMNA | |
| SCHEMBL21318962 | 0.77 | ALDH1A1 (0.31) | KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3294740-B1 | NOVEL SULFONIMIDOYLPURINONE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |