Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21318942 | 0.91 | KMT2A (0.34) | MEN1KMT2ANPSR1ADORA3ALDH1A1 | |
| SCHEMBL21318981 | 0.88 | TOP2A (0.33) | ADORA3GAAMAPTTHRB | |
| SCHEMBL19945779 | 0.87 | MEN1 (0.36) | MEN1KMT2ANPSR1KDM4EALDH1A1 | |
| SCHEMBL21318973 | 0.85 | — | — | |
| SCHEMBL21319054 | 0.85 | ADORA3 (0.43) | KMT2AKDM4EADORA3TLR7 | |
| SCHEMBL21318947 | 0.81 | USP28 (0.39) | ADORA3ALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL21318984 | 0.78 | KMT2A (0.34) | MEN1KMT2ANPSR1ADORA3ALDH1A1 | |
| SCHEMBL21318963 | 0.78 | TSHR (0.31) | TSHRL3MBTL1 | |
| SCHEMBL19945665 | 0.77 | ABCB1 (0.38) | KMT2AADORA3ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL21318986 | 0.76 | ADORA3 (0.31) | MEN1KMT2AKDM4EADORA3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3294740-B1 | NOVEL SULFONIMIDOYLPURINONE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |