Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16381880 | 0.81 | ERN1 (0.46) | ERN1POLBPTPN1MEN1KMT2A | |
| SCHEMBL2892422 | 0.80 | ABCC9 (0.55) | ERN1POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL5084950 | 0.79 | KDM1A (0.50) | ERN1POLBPTPN1MEN1KMT2A | |
| SCHEMBL28037608 | 0.77 | EGFR (0.39) | POLBMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL31536849 | 0.77 | KDM1A (0.54) | POLBALDH1A1MAPTLMNAGAA | |
| SCHEMBL7539767 | 0.76 | GAA (0.53) | ERN1POLBPTPN1MEN1KMT2A | |
| SCHEMBL15427702 | 0.76 | KCNJ11 (0.42) | ERN1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL6171290 | 0.75 | MAPT (0.38) | ERN1POLBPTPN1MEN1KMT2A | |
| SCHEMBL2049662 | 0.75 | TSHR (0.54) | ERN1POLBPTPN1MEN1KMT2A | |
| SCHEMBL29951280 | 0.75 | TSHR (0.54) | ERN1POLBPTPN1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569434-B1 | COMPOSITIONS AND METHODS FOR TREATING LEUKEMIA AND RELATED DISORDERS | DANA FARBER CANCER INST INC (US) | 2019-09-04 | — | — | EP | disclosed |