Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 9/20 | 0.39 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.39 |
| ▸ | ATXN2 | Q99700 | 7/20 | 0.38 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | ABAT | P80404 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16962367 | 1.00 | ENPP2 (0.39) | ENPP2DGAT2ATXN2GPR52ROCK2 | |
| SCHEMBL21323349 | 0.89 | ENPP2 (0.43) | ENPP2DGAT2ATXN2SIGMAR1TLR9 | |
| SCHEMBL16962369 | 0.89 | ENPP2 (0.43) | ENPP2DGAT2ATXN2SIGMAR1TLR9 | |
| SCHEMBL16962454 | 0.85 | ENPP2 (0.53) | ENPP2DGAT2ATXN2HTR2AABAT | |
| SCHEMBL16963580 | 0.85 | ENPP2 (0.35) | ENPP2ATXN2GPR52ROCK2NAMPT | |
| SCHEMBL21323373 | 0.84 | ATXN2 (0.41) | ENPP2DGAT2ATXN2TLR9TLR8 | |
| SCHEMBL21323395 | 0.84 | ENPP2 (0.41) | ENPP2DGAT2ATXN2ROCK2 | |
| SCHEMBL16963800 | 0.84 | ATXN2 (0.41) | ENPP2DGAT2ATXN2TLR9TLR8 | |
| SCHEMBL16963057 | 0.84 | ENPP2 (0.41) | ENPP2DGAT2ATXN2ROCK2 | |
| SCHEMBL16963648 | 0.84 | ENPP2 (0.46) | ENPP2DGAT2ATXN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900669-B1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND RELATED COMPOUNDS AS AUTOTAXIN (ATX) INHIBITORS AND AS INHIBITORS OF THE LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION FOR TREATING E.G. RENAL DISEASES | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |