Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 6/20 | 0.57 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.57 |
| ▸ | ATXN2 | Q99700 | 4/20 | 0.56 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | LSS | P48449 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 3/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16963383 | 1.00 | ENPP2 (0.57) | ENPP2DGAT2ATXN2GPBAR1MAPK8 | |
| SCHEMBL16963684 | 1.00 | ENPP2 (0.57) | ENPP2DGAT2ATXN2GPBAR1MAPK8 | |
| SCHEMBL16963033 | 1.00 | ENPP2 (0.57) | ENPP2DGAT2ATXN2GPBAR1MAPK8 | |
| SCHEMBL16759797 | 0.95 | ENPP2 (0.56) | ENPP2DGAT2ATXN2GPBAR1MAPK8 | |
| SCHEMBL22911027 | 0.95 | ENPP2 (0.56) | ENPP2DGAT2ATXN2GPBAR1MAPK8 | |
| SCHEMBL16963324 | 0.94 | ENPP2 (0.55) | ENPP2DGAT2ATXN2GPBAR1MAPK8 | |
| SCHEMBL17310877 | 0.94 | ENPP2 (0.55) | ENPP2DGAT2ATXN2GPBAR1MAPK8 | |
| SCHEMBL17310878 | 0.94 | ENPP2 (0.55) | ENPP2DGAT2ATXN2GPBAR1MAPK8 | |
| SCHEMBL16963244 | 0.89 | ENPP2 (0.47) | ENPP2DGAT2ATXN2KDM4EKMT2A | |
| SCHEMBL21323023 | 0.89 | ENPP2 (0.51) | ENPP2DGAT2ATXN2LIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590940-B1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND RELATED COMPOUNDS AS AUTOTAXIN (ATX) INHIBITORS AND AS INHIBITORS OF THE LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION FOR TREATING E.G. RENAL DISEASES | HOFFMANN LA ROCHE (CH) | 2021-06-09 | — | — | EP | disclosed |
| EP-2900669-B1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND RELATED COMPOUNDS AS AUTOTAXIN (ATX) INHIBITORS AND AS INHIBITORS OF THE LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION FOR TREATING E.G. RENAL DISEASES | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |