Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 11/20 | 0.51 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.51 |
| ▸ | ATXN2 | Q99700 | 12/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.34 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16963143 | 1.00 | ENPP2 (0.51) | ENPP2DGAT2ATXN2CYP3A4DPP4 | |
| SCHEMBL22607355 | 0.92 | ENPP2 (0.49) | ENPP2DGAT2ATXN2LIPEHSD11B1 | |
| SCHEMBL21323097 | 0.89 | ENPP2 (0.57) | ENPP2DGAT2ATXN2LIPE | |
| SCHEMBL16963684 | 0.89 | ENPP2 (0.57) | ENPP2DGAT2ATXN2LIPE | |
| SCHEMBL16963383 | 0.89 | ENPP2 (0.57) | ENPP2DGAT2ATXN2LIPE | |
| SCHEMBL16963033 | 0.89 | ENPP2 (0.57) | ENPP2DGAT2ATXN2LIPE | |
| SCHEMBL21323395 | 0.88 | ENPP2 (0.41) | ENPP2DGAT2ATXN2CYP3A4DPP4 | |
| SCHEMBL16963057 | 0.88 | ENPP2 (0.41) | ENPP2DGAT2ATXN2CYP3A4DPP4 | |
| SCHEMBL21322969 | 0.88 | ENPP2 (0.61) | ENPP2DGAT2ATXN2CYP3A4DPP4 | |
| SCHEMBL16963187 | 0.88 | ENPP2 (0.61) | ENPP2DGAT2ATXN2CYP3A4DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900669-B1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND RELATED COMPOUNDS AS AUTOTAXIN (ATX) INHIBITORS AND AS INHIBITORS OF THE LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION FOR TREATING E.G. RENAL DISEASES | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |