Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 3/20 | 0.47 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.47 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | ATXN2 | Q99700 | 9/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.34 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.34 |
| ▸ | LIPE | Q05469 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16963397 | 1.00 | ENPP2 (0.47) | ENPP2DGAT2TBK1ATXN2NPC1 | |
| SCHEMBL16963395 | 1.00 | ENPP2 (0.47) | ENPP2DGAT2TBK1ATXN2NPC1 | |
| SCHEMBL16962689 | 0.88 | ENPP2 (0.49) | ENPP2DGAT2ATXN2NPC1RAB9A | |
| SCHEMBL21323239 | 0.88 | ENPP2 (0.49) | ENPP2DGAT2ATXN2TLR9TLR8 | |
| SCHEMBL16962688 | 0.88 | ENPP2 (0.49) | ENPP2DGAT2ATXN2NPC1RAB9A | |
| SCHEMBL16963314 | 0.88 | ENPP2 (0.49) | ENPP2DGAT2ATXN2TLR9TLR8 | |
| SCHEMBL21323020 | 0.88 | ENPP2 (0.49) | ENPP2DGAT2ATXN2NPC1RAB9A | |
| SCHEMBL16963317 | 0.88 | ENPP2 (0.49) | ENPP2DGAT2ATXN2TLR9TLR8 | |
| SCHEMBL21323007 | 0.87 | ENPP2 (0.56) | ENPP2DGAT2ATXN2LIPE | |
| SCHEMBL16962303 | 0.87 | ENPP2 (0.56) | ENPP2DGAT2ATXN2LIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900669-B1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND RELATED COMPOUNDS AS AUTOTAXIN (ATX) INHIBITORS AND AS INHIBITORS OF THE LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION FOR TREATING E.G. RENAL DISEASES | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |