Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 8/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.37 |
| ▸ | P4HB | P07237 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16963560 | 1.00 | GPR183 (0.49) | GPR183KCNH2ATXN2MAOBHDAC1 | |
| SCHEMBL16963565 | 1.00 | GPR183 (0.49) | GPR183KCNH2ATXN2MAOBHDAC1 | |
| SCHEMBL16963465 | 0.89 | GPR183 (0.39) | GPR183KCNH2ATXN2HDAC1ENPP2 | |
| SCHEMBL21323309 | 0.89 | GPR183 (0.39) | GPR183KCNH2ATXN2HDAC1ENPP2 | |
| SCHEMBL16963089 | 0.89 | GPR183 (0.39) | GPR183KCNH2ATXN2HDAC1ENPP2 | |
| SCHEMBL21323359 | 0.88 | ATXN2 (0.41) | GPR183ATXN2ENPP2DGAT2 | |
| SCHEMBL21322991 | 0.88 | ENPP2 (0.51) | GPR183KCNH2ATXN2STAT3ENPP2 | |
| SCHEMBL16962289 | 0.88 | ENPP2 (0.51) | GPR183KCNH2ATXN2STAT3ENPP2 | |
| SCHEMBL16962996 | 0.88 | ATXN2 (0.41) | GPR183ATXN2ENPP2DGAT2 | |
| SCHEMBL16963775 | 0.88 | ENPP2 (0.51) | GPR183KCNH2ATXN2STAT3ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900669-B1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND RELATED COMPOUNDS AS AUTOTAXIN (ATX) INHIBITORS AND AS INHIBITORS OF THE LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION FOR TREATING E.G. RENAL DISEASES | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |