Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | CPS1 | P31327 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16962815 | 1.00 | ATM (0.42) | ATMLMNAKMT2AMEN1TLR9 | |
| SCHEMBL16963195 | 0.91 | ENPP2 (0.45) | ENPP2ATXN2 | |
| SCHEMBL22607225 | 0.91 | ENPP2 (0.45) | ENPP2ATXN2 | |
| SCHEMBL21323015 | 0.91 | ENPP2 (0.45) | ENPP2ATXN2 | |
| SCHEMBL21323016 | 0.91 | ENPP2 (0.45) | ENPP2ATXN2 | |
| SCHEMBL16962814 | 0.89 | ATXN2 (0.39) | LMNAKMT2AMEN1TLR9TLR8 | |
| SCHEMBL21322858 | 0.89 | ATXN2 (0.39) | LMNAKMT2AMEN1TLR9TLR8 | |
| SCHEMBL16962785 | 0.84 | ENPP2 (0.46) | TLR9TLR8TLR7ENPP2ATXN2 | |
| SCHEMBL21323110 | 0.84 | ENPP2 (0.46) | TLR9TLR8TLR7ENPP2ATXN2 | |
| SCHEMBL16963051 | 0.81 | KDM4E (0.42) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900669-B1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND RELATED COMPOUNDS AS AUTOTAXIN (ATX) INHIBITORS AND AS INHIBITORS OF THE LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION FOR TREATING E.G. RENAL DISEASES | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |