Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 3/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | P4HB | P07237 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2719231 | 0.84 | KDM4E (0.45) | KDM4EALDH1A1CXCR2HIF1AMEN1 | |
| SCHEMBL2132598 | 0.80 | PDK2 (0.43) | KDM4EALDH1A1CXCR2HIF1AMAOB | |
| SCHEMBL2134432 | 0.79 | KDM4E (0.42) | KDM4EALDH1A1MEN1KMT2AMAOB | |
| SCHEMBL2719235 | 0.76 | L3MBTL1 (0.42) | KDM4EALDH1A1CXCR2HIF1AUCHL1 | |
| SCHEMBL2132595 | 0.75 | CXCR2 (0.37) | KDM4EALDH1A1CXCR2HIF1AUCHL1 | |
| SCHEMBL2137466 | 0.75 | BRD4 (0.47) | UCHL1MAOB | |
| SCHEMBL10176513 | 0.72 | DGAT1 (0.54) | CXCR2HIF1AUCHL1AAK1 | |
| SCHEMBL21114036 | 0.72 | KDM4E (0.40) | KDM4EALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL13202141 | 0.71 | CXCR2 (0.49) | CXCR2HIF1AUCHL1 | |
| SCHEMBL31111411 | 0.70 | L3MBTL1 (0.35) | CXCR2HIF1AUCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120101136-A1 | 5-MEMBERED HETEROARYL DERIVATIVES USED AS SPHINGOSINE 1- PHOSPHATE RECEPTOR AGONISTS | GLAXO GROUP LIMITED | 2012-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101136-A1 | 5-MEMBERED HETEROARYL DERIVATIVES USED AS SPHINGOSINE 1- PHOSPHATE RECEPTOR AGONISTS | S1PR1, S1PR5, S1PR3 | KDM4E 3897/4885ALDH1A1 2923/4885CXCR2 789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.