Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | DDX3X | O00571 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL213026 | 0.94 | RAB9A (0.45) | KDM4ERAB9ANPC1KMT2AMAPT | |
| SCHEMBL211215 | 0.94 | CSNK2A2 (0.39) | KDM4ERAB9ANPC1KMT2AMAPT | |
| SCHEMBL211918 | 0.94 | RXFP1 (0.40) | KDM4ERAB9ANPC1KMT2AMAPT | |
| SCHEMBL211534 | 0.94 | CSNK2A2 (0.40) | KDM4ERAB9ANPC1KMT2ASMN1; SMN2 | |
| SCHEMBL212054 | 0.93 | CSNK2A2 (0.38) | KDM4ERAB9ANPC1KMT2AMAPT | |
| SCHEMBL212239 | 0.93 | CSNK2A2 (0.38) | KDM4ERAB9ANPC1KMT2AMAPT | |
| SCHEMBL211530 | 0.91 | CSNK2A2 (0.37) | KDM4ERAB9ANPC1KMT2AMAPT | |
| SCHEMBL213354 | 0.91 | KDM4E (0.43) | KDM4ERAB9ANPC1KMT2AMAPT | |
| SCHEMBL213581 | 0.88 | CSNK2A2 (0.42) | KDM4ERAB9ANPC1KMT2ASMN1; SMN2 | |
| SCHEMBL211757 | 0.88 | CSNK2A2 (0.41) | KDM4ERAB9ANPC1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |