Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | SHMT2 | P34897 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21326688 | 0.86 | IRAK4 (0.43) | GAAALDH1A1HPGDHSD17B10ALOX15 | |
| SCHEMBL21326720 | 0.78 | IRAK4 (0.42) | ALDH1A1HPGDHSD17B10TSHRIRAK4 | |
| SCHEMBL21326701 | 0.76 | IRAK4 (0.44) | GAAALDH1A1HPGDHSD17B10ALOX15 | |
| SCHEMBL21326707 | 0.74 | CYP1A2 (0.41) | GAAALDH1A1IRAK4KDM4ECYP1A2 | |
| SCHEMBL19504487 | 0.65 | HRH3 (0.40) | GAASHMT2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL30291447 | 0.65 | GAA (0.43) | GAASMN1; SMN2PIK3CBPIK3CDPIK3CA | |
| SCHEMBL30291553 | 0.65 | GAA (0.43) | GAASMN1; SMN2PIK3CBPIK3CDPIK3CA | |
| SCHEMBL21326692 | 0.64 | IRAK4 (0.51) | ALDH1A1HPGDHSD17B10TSHRIRAK4 | |
| SCHEMBL17531163 | 0.62 | ALDH1A1 (0.50) | GAAALDH1A1HPGDHSD17B10ALOX15 | |
| SCHEMBL17624437 | 0.61 | HRH4 (0.46) | GAAALDH1A1HPGDHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109890829-B | Pyrazolo [1,5a ] pyrimidine derivatives as IRAK4 modulators | 豪夫迈·罗氏有限公司 | 2022-07-15 | — | — | CN | disclosed |
| EP-3535273-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | H. Hoffnabb-La Roche Ag (CH) | 2019-09-11 | — | — | EP | disclosed |