Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 9/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KHK | P50053 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21326692 | 0.87 | IRAK4 (0.51) | IRAK4ALDH1A1KDM4EHPGDTSHR | |
| SCHEMBL21326707 | 0.82 | CYP1A2 (0.41) | IRAK4ALDH1A1KDM4EMAPK1MAPT | |
| SCHEMBL21326611 | 0.82 | IRAK4 (0.46) | IRAK4ALDH1A1KDM4EHPGDTSHR | |
| SCHEMBL21326715 | 0.78 | GAA (0.37) | IRAK4ALDH1A1KDM4EHPGDTSHR | |
| SCHEMBL21326643 | 0.77 | IRAK4 (0.52) | IRAK4ALDH1A1KDM4EHPGDTSHR | |
| SCHEMBL29773937 | 0.74 | IRAK4 (0.37) | IRAK4 | |
| SCHEMBL23093807 | 0.72 | CYP1A2 (0.43) | IRAK4ALDH1A1MAPK1MAPTLMNA | |
| SCHEMBL22344222 | 0.71 | IRAK4 (0.38) | IRAK4ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL21326696 | 0.69 | IRAK4 (0.51) | IRAK4 | |
| SCHEMBL21326651 | 0.69 | IRAK4 (0.51) | IRAK4ALDH1A1KDM4EMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109890829-B | Pyrazolo [1,5a ] pyrimidine derivatives as IRAK4 modulators | 豪夫迈·罗氏有限公司 | 2022-07-15 | — | — | CN | disclosed |
| EP-3535273-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | H. Hoffnabb-La Roche Ag (CH) | 2019-09-11 | — | — | EP | disclosed |