Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7794720 | 0.81 | AHR (0.51) | AHRHPGDMAPTMAOAALDH1A1 | |
| SCHEMBL24182074 | 0.80 | AHR (0.50) | AHRHPGDMAPTMAOAALDH1A1 | |
| SCHEMBL7015222 | 0.79 | AHR (0.54) | AHRHPGDMAPTMAOAALDH1A1 | |
| SCHEMBL18826569 | 0.78 | HPGD (0.71) | AHRHPGDMAPTMAOAALDH1A1 | |
| SCHEMBL10913894 | 0.77 | AHR (0.47) | AHRHPGDMAPTMAOAALDH1A1 | |
| SCHEMBL18669039 | 0.76 | SMN1; SMN2 (0.57) | AHRHPGDMAPTMAOAALDH1A1 | |
| SCHEMBL10909799 | 0.76 | POLB (0.46) | AHRHPGDMAPTMAOAALDH1A1 | |
| SCHEMBL1307183 | 0.74 | NPC1 (0.62) | GAACASP3KMT2AMEN1POLB | |
| SCHEMBL18669229 | 0.72 | AHR (0.47) | AHRHPGDMAPTMAOAALDH1A1 | |
| SCHEMBL18669027 | 0.72 | GRM5 (0.50) | AHRHPGDMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3142748-B1 | USE OF PDE4 INHIBITORS AND COMBINATIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | CELGENE CORP (US) | 2019-09-11 | — | — | EP | disclosed |