Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 9/20 | 0.65 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13202776 | 0.91 | EPAS1 (0.59) | EPAS1EPHX2ACHEALDH1A1MAPT | |
| SCHEMBL13202796 | 0.84 | EPAS1 (0.56) | EPAS1EPHX2ACHEALDH1A1MAPT | |
| SCHEMBL6108893 | 0.82 | EPAS1 (0.50) | EPAS1EPHX2ACHEALDH1A1MAPT | |
| SCHEMBL2977289 | 0.81 | EPAS1 (0.53) | EPAS1EPHX2ACHEALDH1A1MAPT | |
| SCHEMBL9361501 | 0.79 | EPAS1 (1.00) | EPAS1EPHX2ACHEALDH1A1MAPT | |
| SCHEMBL29791659 | 0.79 | EPAS1 (1.00) | EPAS1EPHX2ACHEALDH1A1MAPT | |
| SCHEMBL2974074 | 0.78 | HTR1A (0.51) | EPAS1ALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL3854234 | 0.78 | SMN1; SMN2 (0.51) | EPAS1ACHEHTTSMN1; SMN2 | |
| Etisazole SCHEMBL2109479 | 0.77 | EPAS1 (0.56) | EPAS1EPHX2ACHEALDH1A1MAPT | |
| Etisazole SCHEMBL30496100 | 0.77 | EPAS1 (0.56) | EPAS1EPHX2ACHEALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-B1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO LTD (CN) | 2019-09-11 | — | — | EP | disclosed |