Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.56 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.42 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18436754 | 0.87 | GPR119 (0.56) | GPR119ALDH1A1LMNAMAPT | |
| SCHEMBL24681357 | 0.86 | GPR119 (0.43) | GPR119RORCNR1H2NR1H3ALDH1A1 | |
| SCHEMBL19001024 | 0.86 | HSD11B1 (0.51) | GPR119RORCALDH1A1LMNAMAPT | |
| SCHEMBL6073574 | 0.86 | GPR119 (0.43) | GPR119NR1H2ALDH1A1LMNAMAPT | |
| SCHEMBL5726247 | 0.86 | GPR119 (0.43) | GPR119NR1H2ALDH1A1LMNAMAPT | |
| SCHEMBL5782035 | 0.85 | GPR119 (0.46) | GPR119NR1H2NR1H3 | |
| SCHEMBL7661674 | 0.85 | GPR119 (0.58) | GPR119ALDH1A1LMNAMAPT | |
| SCHEMBL7661671 | 0.85 | GPR119 (0.58) | GPR119ALDH1A1LMNAMAPT | |
| SCHEMBL21142472 | 0.84 | GPR119 (0.54) | GPR119RORCABCB1NR1H2NR1H3 | |
| SCHEMBL19838611 | 0.84 | GPR119 (0.54) | GPR119RORCABCB1NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-B1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO LTD (CN) | 2019-09-11 | — | — | EP | disclosed |