Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 15/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.34 |
| ▸ | EED | O75530 | 1/20 | 0.34 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.34 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.34 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16806438 | 0.93 | KIT (0.36) | PIK3CDKITFLT3BTKPIK3CG | |
| SCHEMBL21337663 | 0.92 | PIK3CD (0.34) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| Formic Acid SCHEMBL16783606 | 0.91 | KIT (0.35) | PIK3CDKITFLT3BTKPIK3CG | |
| SCHEMBL21337803 | 0.90 | PIK3CD (0.38) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL16783895 | 0.88 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL21337760 | 0.86 | PIK3CD (0.46) | PIK3CDBTKPIK3CAPIK3CBPIK3CG | |
| Formic Acid SCHEMBL16783395 | 0.86 | PIK3CD (0.46) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL16806437 | 0.85 | PIK3CD (0.32) | PIK3CDPIK3CBPIK3CGHTTNPSR1 | |
| SCHEMBL21337664 | 0.85 | PIK3CD (0.40) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL21337788 | 0.84 | ATR (0.39) | PIK3CDBTKPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083617-B1 | ISOCHROMENE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARM SPA (IT) | 2019-09-11 | — | — | EP | disclosed |