Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 2/20 | 0.40 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 6/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 6/20 | 0.38 |
| ▸ | SRC | P12931 | 4/20 | 0.37 |
| ▸ | EGFR | P00533 | 3/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | HCK | P08631 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16783524 | 0.93 | PDK4 (0.41) | PIK3CDPDK4BTKATRTNK2 | |
| SCHEMBL21337803 | 0.90 | PIK3CD (0.38) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL16783505 | 0.87 | ATR (0.38) | PIK3CDPDK4BTKATRTNK2 | |
| SCHEMBL16806454 | 0.87 | PIK3CD (0.49) | PIK3CDSRCEGFRABL1HCK | |
| SCHEMBL21337666 | 0.86 | PIK3CD (0.36) | PIK3CDBTKPIK3CAPIK3CBPIK3CG | |
| SCHEMBL21337664 | 0.85 | PIK3CD (0.40) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL21337788 | 0.84 | ATR (0.39) | PIK3CDBTKATRPIK3CAPIK3CB | |
| SCHEMBL21337663 | 0.83 | PIK3CD (0.34) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL16783545 | 0.82 | LNPEP (0.39) | PIK3CDGRM5SRCABL1PIK3CA | |
| SCHEMBL16783442 | 0.82 | PIK3CD (0.35) | PIK3CDEGFRPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083617-B1 | ISOCHROMENE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARM SPA (IT) | 2019-09-11 | — | — | EP | disclosed |