Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23882903 | 0.81 | MAPT (0.61) | MAPTLMNAGAAHPGDCASP3 | |
| SCHEMBL23882952 | 0.81 | MAPT (0.61) | MAPTLMNAGAAHPGDCASP3 | |
| SCHEMBL8017634 | 0.81 | SMN1; SMN2 (0.55) | MAPTLMNAGAAHPGDHTT | |
| SCHEMBL3239740 | 0.78 | LMNA (0.66) | MAPTLMNAGAAHPGDCASP3 | |
| SCHEMBL477506 | 0.76 | LMNA (0.63) | MAPTLMNAGAAHPGDCASP3 | |
| SCHEMBL1921464 | 0.75 | CYP19A1 (0.46) | MAPTLMNAGAAHPGDMAPK1 | |
| SCHEMBL4857317 | 0.74 | L3MBTL1 (0.39) | LMNAGAAMAPK1SLC6A2SLC6A3 | |
| SCHEMBL23610037 | 0.73 | MAPT (0.59) | MAPTLMNAGAAHPGDCASP3 | |
| SCHEMBL23610035 | 0.73 | MAPT (0.59) | MAPTLMNAGAAHPGDCASP3 | |
| SCHEMBL2687958 | 0.73 | LMNA (0.56) | MAPTLMNAGAAHPGDCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3405192-B1 | BRUTON'S TYROSINE KINASE INHIBITORS | ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO LTD (CN) | 2024-12-11 | — | — | EP | disclosed |
| CN-109310671-B | Bruton's tyrosine kinase inhibitors | 淄博百极常生制药有限公司 | 2021-08-06 | — | — | CN | disclosed |
| US-10793566-B2 | Bruton's tyrosine kinase inhibitors | ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD. (CN) | 2020-10-06 | — | — | US | disclosed |
| US-10662187-B2 | Bruton's tyrosine kinase inhibitors | ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD. (CN) | 2020-05-26 | — | — | US | disclosed |
| US-10662187-B2 | Bruton's tyrosine kinase inhibitors | ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD. (CN) | 2020-05-26 | — | — | US | disclosed |
| US-20190276453-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2019-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10662187-B2 | Bruton's tyrosine kinase inhibitors | BTK, ABL1, SYK | MAPT 4353/4885LMNA 4171/4885GAA 2295/4885 |
| US-10793566-B2 | Bruton's tyrosine kinase inhibitors | BTK, ABL1, SYK | MAPT 4353/4885LMNA 4171/4885GAA 2295/4885 |
| US-20190276453-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | BTK, ABL1, SYK | MAPT 4353/4885LMNA 4171/4885GAA 2295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.