SCHEMBL21344757

SCHEMBL21344757

CC#Cc1cc(C)c(C2C(=O)CC3(CCN(C(=O)NOCC)CC3)CC2=O)c(C)c1

nearest known ligand 0.31

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.31
ACACA Q13085 1/20 0.31
MAPK1 P28482 1/20 0.31
KMT2A Q03164 2/20 0.31
CYP2D6 P10635 1/20 0.31
HSD17B10 Q99714 1/20 0.31
GABRA1 P14867 1/20 0.30
GABRG2 P18507 1/20 0.30
GABRB3 P28472 1/20 0.30
GABRA5 P31644 1/20 0.30
GABRA3 P34903 1/20 0.30
GABRA2 P47869 1/20 0.30
GABRB2 P47870 1/20 0.30
BTK Q06187 1/20 0.30
GRM5 P41594 1/20 0.30
MEN1 O00255 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22992125 0.90 CYP2D6 (0.33) MAPK1CYP2D6HSD17B10GRM5
SCHEMBL22992121 0.89 KMT2A (0.36) KMT2A
SCHEMBL21344260 0.88
SCHEMBL22992095 0.88 PIK3CA (0.34) CYP2D6HSD17B10GRM5
SCHEMBL21344864 0.87 CYP3A4 (0.32) CYP2D6HSD17B10BTK
SCHEMBL24324811 0.87 MAPT (0.37) L3MBTL1MAPK1KMT2AGABRA1GABRG2
SCHEMBL21344248 0.86 HIF1A (0.32)
SCHEMBL22992227 0.85 GRM5 (0.42) MAPK1KMT2ACYP2D6HSD17B10GRM5
SCHEMBL23344433 0.85 OPRM1 (0.34) KMT2AMEN1
SCHEMBL21344863 0.85 ADAM17 (0.38) L3MBTL1MAPK1KMT2AGRM5MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12043599-B2 Herbicidal compounds SYNGENTA PARTICIPATIONS AG (CH) 2024-07-23 US disclosed
EP-3762378-B1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2022-05-18 EP disclosed
US-20210047274-A1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2021-02-18 US disclosed
WO-2019170745-A1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2019-09-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210047274-A1 HERBICIDAL COMPOUNDS DDT, CBR3, GLRX3 L3MBTL1 1183/4885ACACA 1342/4885MAPK1 3826/4885
US-12043599-B2 Herbicidal compounds DDT, CBR3, GLRX3 L3MBTL1 1183/4885ACACA 1342/4885MAPK1 3826/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.