SCHEMBL213466

SCHEMBL213466

C(=N/O[Si](Cc1ccccc1)(Cc1ccccc1)Cc1ccccc1)\c1cccs1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLA2G7 Q13093 1/20 0.51
G6PC1 P35575 1/20 0.50
L3MBTL1 Q9Y468 2/20 0.47
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
ALDH1A1 P00352 5/20 0.46
TSHR P16473 1/20 0.46
HTT P42858 2/20 0.45
SMN1; SMN2 Q16637 5/20 0.44
RAB9A P51151 3/20 0.44
GAA P10253 2/20 0.44
PLA2G1B P04054 1/20 0.44
ATG4B Q9Y4P1 1/20 0.44
NPC1 O15118 1/20 0.44
LMNA P02545 2/20 0.43
CYP1A2 P05177 1/20 0.39
MAPT P10636 2/20 0.38
THRB P10828 1/20 0.38
BLM P54132 1/20 0.38
HPGD P15428 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL213467 1.00 PLA2G7 (0.51) PLA2G7G6PC1L3MBTL1MEN1KMT2A
SCHEMBL214856 0.77 PLA2G7 (0.43) PLA2G7G6PC1L3MBTL1MEN1KMT2A
SCHEMBL214857 0.77 PLA2G7 (0.43) PLA2G7G6PC1L3MBTL1MEN1KMT2A
SCHEMBL213937 0.77 TRPA1 (0.38) L3MBTL1MEN1KMT2ATSHRHTT
SCHEMBL212839 0.76 PLA2G7 (0.51) PLA2G7G6PC1L3MBTL1MEN1KMT2A
SCHEMBL212838 0.76 PLA2G7 (0.51) PLA2G7G6PC1L3MBTL1MEN1KMT2A
SCHEMBL214078 0.74 SMN1; SMN2 (0.53) PLA2G7G6PC1L3MBTL1MEN1KMT2A
SCHEMBL214077 0.74 SMN1; SMN2 (0.53) PLA2G7G6PC1L3MBTL1MEN1KMT2A
SCHEMBL214848 0.72 TP53 (0.33) ALDH1A1TSHR
SCHEMBL214849 0.72 TP53 (0.33) ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8088868-B2 oximation of cojugated homopolymers formed by addtion polymerization of conjugated diene monomer in the presence lanthanide copmpounds as polymerization catalysts; polymers used in the manufacture of tires having reduced hysteresis BRIDGESTONE CORPORATION (JP) 2012-01-03 US claimed
US-20080146745-A1 POLYMERS FUNCTIONALIZED WITH PROTECTED OXIME COMPOUNDS BRIDGESTONE CORPORATION (JP) 2008-06-19 US claimed
US-8088868-B2 oximation of cojugated homopolymers formed by addtion polymerization of conjugated diene monomer in the presence lanthanide copmpounds as polymerization catalysts; polymers used in the manufacture of tires having reduced hysteresis BRIDGESTONE CORPORATION (JP) 2012-01-03 US disclosed
US-20080146745-A1 POLYMERS FUNCTIONALIZED WITH PROTECTED OXIME COMPOUNDS BRIDGESTONE CORPORATION (JP) 2008-06-19 US disclosed