Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.77 |
| ▸ | THRB | P10828 | 1/20 | 0.77 |
| ▸ | GAK | O14976 | 4/20 | 0.67 |
| ▸ | SRC | P12931 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.54 |
| ▸ | COQ8A | Q8NI60 | 2/20 | 0.54 |
| ▸ | NLK | Q9UBE8 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21121126 | 0.85 | GAK (0.65) | POLBTHRBGAKSRCMAPT | |
| SCHEMBL19283173 | 0.83 | GAK (0.66) | POLBTHRBGAKMAPTMEN1 | |
| SCHEMBL30307397 | 0.83 | GAK (0.66) | POLBTHRBGAKMAPTMEN1 | |
| SCHEMBL21121619 | 0.82 | POLB (0.67) | POLBTHRBGAKMAPTMEN1 | |
| SCHEMBL26087302 | 0.82 | SRC (0.62) | POLBTHRBGAKSRCMAPT | |
| Hydrochloric Acid SCHEMBL22029285 | 0.81 | POLB (0.65) | POLBTHRBGAKMAPTMEN1 | |
| SCHEMBL7501815 | 0.81 | CYP1A2 (0.62) | POLBTHRBGAKNR4A2KDM4E | |
| SCHEMBL21121575 | 0.81 | GAK (0.77) | POLBTHRBGAKSRCMAPT | |
| SCHEMBL19633693 | 0.80 | GAK (0.65) | POLBTHRBGAKMAPTKMT2A | |
| SCHEMBL11834679 | 0.79 | GAK (0.57) | POLBTHRBGAKSRCMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019173482-A1 | 4-AMINOQUINOLINE COMPOUNDS FOR THE TREATMENT OF ANGIOGENESIS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2019-09-12 | — | — | WO | disclosed |