SCHEMBL19633693

SCHEMBL19633693

COc1cccc(Nc2ccnc3cc(Cl)ccc23)c1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAK O14976 5/20 0.65
APP P05067 2/20 0.60
NR4A2 P43354 1/20 0.60
FADS1 O60427 1/20 0.59
MAPT P10636 2/20 0.57
GAA P10253 1/20 0.57
ATM Q13315 1/20 0.57
POLB P06746 1/20 0.57
THRB P10828 1/20 0.57
RIPK2 O43353 2/20 0.56
COQ8A Q8NI60 2/20 0.56
NLK Q9UBE8 2/20 0.56
EGFR P00533 2/20 0.53
ERBB3 P21860 1/20 0.53
PIK3CA P42336 1/20 0.53
PIK3CB P42338 1/20 0.53
PIK3CG P48736 1/20 0.53
CYP1A2 P05177 2/20 0.52
CYP2D6 P10635 2/20 0.52
CYP2C8 P10632 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19633676 0.90 GAK (0.68) GAKRIPK2COQ8ANLKEGFR
SCHEMBL30420470 0.88 GAK (0.67) GAKRIPK2COQ8ANLKEGFR
Metaquine SCHEMBL7205743 0.87 FADS1 (0.71) GAKAPPNR4A2FADS1MAPT
SCHEMBL19633647 0.86 GAK (0.66) GAKRIPK2COQ8ANLKEGFR
SCHEMBL23706787 0.86 GAK (0.61) GAKMAPTRIPK2COQ8ANLK
SCHEMBL21121632 0.86 MAPT (0.69) GAKAPPNR4A2MAPTGAA
SCHEMBL21121679 0.85 HTT (0.64) GAKRIPK2COQ8ANLKEGFR
SCHEMBL19633799 0.85 GAK (0.60) GAKMAPTGAAATMRIPK2
SCHEMBL21121509 0.85 HTT (0.64) GAKRIPK2COQ8ANLKEGFR
SCHEMBL30420414 0.85 HTT (0.64) GAKRIPK2COQ8ANLKEGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3481806-B1 4-ANILINO-QUINOLINE COMPOUNDS AS ANTI-CANCER AGENTS INST NAT SANTE RECH MED (FR) 2023-06-07 EP claimed
EP-3735407-A1 SUBSTITUTED HALO-QUINOLINE DERIVATES FOR USE IN THE TREATMENT OF LYMPHOMAS AND LEUKEMIA INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM (FR) 2020-11-11 EP claimed
WO-2019134969-A1 SUBSTITUTED HALO-QUINOLINE DERIVATES FOR USE IN THE TREATMENT OF LYMPHOMAS AND LEUKEMIA INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2019-07-11 WO claimed
EP-3735407-A1 SUBSTITUTED HALO-QUINOLINE DERIVATES FOR USE IN THE TREATMENT OF LYMPHOMAS AND LEUKEMIA INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM (FR) 2020-11-11 EP disclosed
WO-2019173482-A1 4-AMINOQUINOLINE COMPOUNDS FOR THE TREATMENT OF ANGIOGENESIS Sanford Burnham Prebys Medical Discovery Institute (US) 2019-09-12 WO disclosed
WO-2019134969-A1 SUBSTITUTED HALO-QUINOLINE DERIVATES FOR USE IN THE TREATMENT OF LYMPHOMAS AND LEUKEMIA INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2019-07-11 WO disclosed
WO-2017198196-A1 QUINOLINE DERIVATIVE HAVING ANTI-TUMOR ACTIVITY 王子厚 2017-11-23 WO disclosed