Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26118486 | 0.87 | HDAC6 (0.40) | HDAC6HDAC4HDAC1GPBAR1CYP2C9 | |
| SCHEMBL12496481 | 0.83 | DAO (0.47) | GRM2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL22901445 | 0.82 | KDM4E (0.48) | GRM2MAPTALDH1A1GAAESR1 | |
| SCHEMBL21350980 | 0.77 | KDM4E (0.47) | HDAC6HDAC4HDAC1HDAC3LMNA | |
| SCHEMBL22901447 | 0.74 | ESR2 (0.34) | GPBAR1RORCGRM2LMNAHTT | |
| SCHEMBL21350988 | 0.73 | ESR2 (0.33) | GPBAR1RORCGRM2ESR1ESR2 | |
| SCHEMBL21350986 | 0.70 | GRM2 (0.36) | GRM2LMNAMAPTKMT2AALDH1A1 | |
| SCHEMBL14310501 | 0.70 | FLT1 (0.46) | LMNAHTTMAPTMEN1POLB | |
| SCHEMBL12497054 | 0.69 | NOTUM (0.49) | MAPTMEN1KMT2AALDH1A1TP53 | |
| SCHEMBL12496564 | 0.68 | DAO (0.44) | LMNAMAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3762376-B1 | DIPHENYL SUBSTITUTED THIOPHENE-2-AMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF USEFUL AS ANTIMICROBIAL | DENOVAMED INC (CA) | 2023-03-01 | — | — | EP | disclosed |
| WO-2019169479-A1 | DIPHENYL SUBSTITUTED THIOPHENE-2-AMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF USEFUL AS ANTIMICROBIAL | DENOVAMED INC. (CA) | 2019-09-12 | — | — | WO | disclosed |