Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.46 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.44 |
| ▸ | SELE | P16581 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12496481 | 0.87 | DAO (0.47) | KDM4EGRM2ALDH1A1GLANOTUM | |
| SCHEMBL21350985 | 0.82 | HDAC6 (0.41) | GRM2BRD4ALDH1A1GAAESR1 | |
| SCHEMBL21350980 | 0.81 | KDM4E (0.47) | KDM4EALDH1A1GAAGLAMAPT | |
| SCHEMBL21350983 | 0.79 | KDM4E (0.45) | KDM4EICAM1SELEALDH1A1GAA | |
| SCHEMBL2847216 | 0.77 | IKBKB (0.49) | KDM4EALDH1A1GAAIKBKBF2 | |
| SCHEMBL22901435 | 0.74 | GRM2 (0.41) | KDM4EGRM2ICAM1SELEBRD4 | |
| SCHEMBL22901441 | 0.73 | CA2 (0.38) | GRM2NOTUMCASP3 | |
| SCHEMBL21350986 | 0.73 | GRM2 (0.36) | GRM2BRD4ALDH1A1NOTUMCASP3 | |
| SCHEMBL12497054 | 0.72 | NOTUM (0.49) | KDM4EALDH1A1NOTUMMAPTHPGD | |
| SCHEMBL2847383 | 0.71 | OPRD1 (0.53) | KDM4EALDH1A1IKBKBMAPTDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3762376-B1 | DIPHENYL SUBSTITUTED THIOPHENE-2-AMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF USEFUL AS ANTIMICROBIAL | DENOVAMED INC (CA) | 2023-03-01 | — | — | EP | disclosed |
| US-11306067-B2 | Diphenyl substituted thiophene-2-amide derivatives and pharmaceutical compositions thereof useful as antimicrobial | DENOVAMED INC. (CA) | 2022-04-19 | — | — | US | disclosed |
| US-20210017147-A1 | Diphenyl Substituted Thiophene-2-Amide Derivatives and Pharmaceutical Compositions Thereof Useful as Antimicrobial | DENOVAMED INC. (CA) | 2021-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11306067-B2 | Diphenyl substituted thiophene-2-amide derivatives and pharmaceutical compositions thereof useful as antimicrobial | MYD88, TPMT, MRPL21 | KDM4E 2270/4885GRM2 3871/4885ICAM1 4247/4885 |
| US-20210017147-A1 | Diphenyl Substituted Thiophene-2-Amide Derivatives and Pharmaceutical Compositions Thereof Useful as Antimicrobial | MYD88, TPMT, MRPL21 | KDM4E 2270/4885GRM2 3871/4885ICAM1 4247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.