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SCHEMBL22901447

SCHEMBL22901447

Cc1cc(Cl)ccc1-c1cc(C(O)(C(F)(F)F)C(F)(F)F)sc1-c1ccc(Cl)cc1C

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ESR2 Q92731 3/20 0.34
▸ ESR1 P03372 2/20 0.34
▸ MLYCD O95822 3/20 0.34
▸ SMN1; SMN2 Q16637 2/20 0.33
▸ GPBAR1 Q8TDU6 1/20 0.33
▸ PDK2 Q15119 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ TSHR P16473 1/20 0.33
▸ HTT P42858 1/20 0.33
▸ NOTUM Q6P988 2/20 0.33
▸ FFAR2 O15552 1/20 0.32
▸ CASP3 P42574 1/20 0.32
▸ GRM2 Q14416 1/20 0.32
▸ CASR P41180 1/20 0.32
▸ AR P10275 2/20 0.31
▸ RORC P51449 2/20 0.31
▸ MEN1 O00255 1/20 0.31
▸ POLB P06746 1/20 0.31
▸ MAPT P10636 1/20 0.31
▸ XBP1 P17861 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26121859 0.89 MLYCD (0.33) MLYCDSMN1; SMN2GPBAR1PDK2LMNA
SCHEMBL26120036 0.89 MLYCD (0.33) MLYCDSMN1; SMN2PDK2LMNATSHR
SCHEMBL26120042 0.86 MLYCD (0.33) ESR2ESR1MLYCDSMN1; SMN2GPBAR1
SCHEMBL21350988 0.74 ESR2 (0.33) ESR2ESR1GPBAR1PDK2NOTUM
SCHEMBL21350985 0.74 HDAC6 (0.41) ESR2ESR1SMN1; SMN2GPBAR1LMNA
SCHEMBL12496439 0.71 ESR1 (0.37) ESR2ESR1NOTUMCASP3GRM2
SCHEMBL12496481 0.70 DAO (0.47) NOTUMGRM2MEN1MAPTKMT2A
SCHEMBL11178747 0.69 PTGS2 (0.49) TSHR
SCHEMBL29719717 0.69 NOTUM (0.53) NOTUMCASP3GRM2POLB
SCHEMBL22901445 0.69 KDM4E (0.48) ESR2ESR1SMN1; SMN2NOTUMCASP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3762376-B1 DIPHENYL SUBSTITUTED THIOPHENE-2-AMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF USEFUL AS ANTIMICROBIAL DENOVAMED INC (CA) 2023-03-01 — — EP disclosed
US-11306067-B2 Diphenyl substituted thiophene-2-amide derivatives and pharmaceutical compositions thereof useful as antimicrobial DENOVAMED INC. (CA) 2022-04-19 — — US disclosed
US-20210017147-A1 Diphenyl Substituted Thiophene-2-Amide Derivatives and Pharmaceutical Compositions Thereof Useful as Antimicrobial DENOVAMED INC. (CA) 2021-01-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11306067-B2 Diphenyl substituted thiophene-2-amide derivatives and pharmaceutical compositions thereof useful as antimicrobial MYD88, TPMT, MRPL21 ESR2 2935/4885ESR1 4112/4885MLYCD 498/4885
US-20210017147-A1 Diphenyl Substituted Thiophene-2-Amide Derivatives and Pharmaceutical Compositions Thereof Useful as Antimicrobial MYD88, TPMT, MRPL21 ESR2 2935/4885ESR1 4112/4885MLYCD 498/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.