Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 20/20 | 0.89 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.89 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.89 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.89 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.89 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.89 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.89 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.89 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.89 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.89 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.89 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29412220 | 0.94 | HDAC6 (1.00) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL31424931 | 0.94 | HDAC6 (1.00) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL19631273 | 0.94 | HDAC6 (1.00) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL21356135 | 0.87 | HDAC6 (0.70) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL26079020 | 0.86 | HDAC6 (0.80) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL19631402 | 0.82 | HDAC6 (1.00) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL30285076 | 0.82 | HDAC6 (1.00) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL28966151 | 0.82 | HDAC6 (1.00) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL6018270 | 0.82 | HDAC6 (0.77) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL6018791 | 0.81 | HDAC6 (0.72) | HDAC6HDAC1HDAC3HDAC2HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250346563-A1 | HISTONE DEACETYLASE 6 INHIBITORS AND METHOD FOR TREATING NEUROPATHIC PAIN | UNIV TAIPEI MEDICAL (TW) | 2025-11-13 | — | — | US | disclosed |
| US-11427544-B2 | Histone deacetylase 6 inhibitors and use thereof | TAIPEI MEDICAL UNIVERSITY (TW) | 2022-08-30 | — | — | US | disclosed |
| US-20220251043-A1 | HISTONE DEACETYLASE 6 INHIBITORS AND METHOD FOR TREATING NEUROPATHIC PAIN | TAIPEI MEDICAL UNIVERSITY (TW) | 2022-08-11 | — | — | US | disclosed |
| EP-3458444-B1 | HISTONE DEACETYLASE 6 INHIBITORS AND USE THEREOF | UNIV TAIPEI MEDICAL (TW) | 2022-06-22 | — | — | EP | disclosed |
| US-20190284141-A1 | HISTONE DEACETYLASE 6 INHIBITORS AND USE THEREOF | DCB-USA LLC (US) | 2019-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190284141-A1 | HISTONE DEACETYLASE 6 INHIBITORS AND USE THEREOF | HDAC1, HDAC11, HDAC7 | HDAC6 7/4885HDAC1 1/4885HDAC3 6/4885 |
| US-20250346563-A1 | HISTONE DEACETYLASE 6 INHIBITORS AND METHOD FOR TREATING NEUROPATHIC PAIN | HDAC1, HDAC3, HDAC5 | HDAC6 4/4885HDAC1 1/4885HDAC3 2/4885 |
| US-20220251043-A1 | HISTONE DEACETYLASE 6 INHIBITORS AND METHOD FOR TREATING NEUROPATHIC PAIN | HDAC1, HDAC3, HDAC2 | HDAC6 9/4885HDAC1 1/4885HDAC3 2/4885 |
| US-11427544-B2 | Histone deacetylase 6 inhibitors and use thereof | HDAC1, HDAC11, HDAC7 | HDAC6 7/4885HDAC1 1/4885HDAC3 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.