Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 1/20 | 0.41 |
| ▸ | MAX | P61244 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 2/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 4/20 | 0.38 |
| ▸ | GFER | P55789 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | MMP14 | P50281 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28100413 | 0.81 | SLC2A1 (0.46) | ERN1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL27978560 | 0.80 | LMNA (0.41) | ERN1KMT2AKDM4EGAAMAPT | |
| SCHEMBL27599847 | 0.79 | PARP1 (0.40) | MEN1KMT2AKDM4EGAAMAPT | |
| SCHEMBL9071311 | 0.74 | ERN1 (0.47) | MYCMAXERN1MEN1KMT2A | |
| SCHEMBL29951387 | 0.74 | ERN1 (0.47) | MYCMAXERN1MEN1KMT2A | |
| SCHEMBL9731516 | 0.72 | EGFR (0.44) | MYCMAXERN1MEN1KMT2A | |
| SCHEMBL9731511 | 0.72 | MYC (0.37) | MYCMAXERN1MEN1KMT2A | |
| SCHEMBL557654 | 0.71 | KDM1A (0.53) | MEN1KMT2AKDM4EGAAMAPT | |
| SCHEMBL29376440 | 0.70 | MYC (0.52) | MYCMAXMEN1KMT2AKDM4E | |
| SCHEMBL9326676 | 0.70 | MYC (0.52) | MYCMAXMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106008373-B | Disubstituted bicyclic derivative and its application as efflux pump inhibitor in antibacterial | 山东大学 | 2019-02-22 | — | — | CN | disclosed |
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |