Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 10/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 9/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | RXRG | P48443 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.45 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2355823 | 0.88 | FFAR1 (0.57) | FFAR4FFAR1PPARGPPARDPPARA | |
| SCHEMBL6062457 | 0.88 | FFAR4 (0.63) | FFAR4FFAR1PPARGPPARDPPARA | |
| SCHEMBL6062657 | 0.87 | FFAR1 (0.56) | FFAR4FFAR1PPARGPPARDPPARA | |
| SCHEMBL2840795 | 0.86 | FFAR4 (0.55) | FFAR4FFAR1LMNAL3MBTL1 | |
| SCHEMBL6063887 | 0.85 | FFAR4 (0.53) | FFAR4FFAR1RXRG | |
| SCHEMBL8984885 | 0.84 | FFAR4 (0.54) | FFAR4FFAR1TP53MDM2LMNA | |
| SCHEMBL585819 | 0.84 | FFAR4 (0.60) | FFAR4FFAR1LMNAPPARDPPARA | |
| SCHEMBL3967976 | 0.84 | FFAR4 (0.51) | FFAR4FFAR1LMNAL3MBTL1PPARG | |
| SCHEMBL6063764 | 0.84 | FFAR1 (0.61) | FFAR4FFAR1PPARD | |
| SCHEMBL3406479 | 0.84 | LTB4R (0.47) | FFAR1LMNAL3MBTL1PPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11685725-B2 | YAP1 inhibitors that target the interaction of YAP1 with OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2023-06-27 | — | — | US | disclosed |
| US-11685725-B2 | YAP1 inhibitors that target the interaction of YAP1 with OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2023-06-27 | — | — | US | disclosed |
| US-20210363128-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. | 2021-11-25 | — | — | US | disclosed |
| US-20210363128-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. | 2021-11-25 | — | — | US | disclosed |
| EP-3765015-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. Lee Moffitt Cancer Center & Research Institute, Inc. (US) | 2021-01-20 | — | — | EP | disclosed |
| CN-111989100-A | YAP1 inhibitors targeting YAP1 interaction with OCT4 | H·李·莫菲特癌症中心研究有限公司 | 2020-11-24 | — | — | CN | disclosed |
| WO-2019178401-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2019-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11685725-B2 | YAP1 inhibitors that target the interaction of YAP1 with OCT4 | YAP1, YES1, MYC | FFAR4 4428/4885FFAR1 4636/4885TP53 121/4885 |
| US-20210363128-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | YAP1, MYC, YES1 | FFAR4 4444/4885FFAR1 4673/4885TP53 121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.