Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cycloserine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.68 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.68 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.68 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cycloserine SCHEMBL21359248 | 1.00 | BLM (0.68) | BLMMEN1GRIN2DLMNACYP3A4 | |
| Levcycloserine SCHEMBL243772 | 0.82 | — | — | |
| Cycloserine SCHEMBL34323 | 0.82 | — | — | |
| Cycloserine SCHEMBL8681114 | 0.82 | BLM (1.00) | BLMMEN1GRIN2DLMNACYP3A4 | |
| Cycloserine SCHEMBL34322 | 0.82 | — | — | |
| Cycloserine SCHEMBL6571320 | 0.80 | — | — | |
| Succinic Acid SCHEMBL21801698 | 0.80 | BLM (0.70) | BLMMEN1GRIN2DLMNACYP3A4 | |
| Succinic Acid SCHEMBL21801699 | 0.80 | BLM (0.70) | BLMMEN1GRIN2DLMNACYP3A4 | |
| Cycloserine SCHEMBL5146943 | 0.77 | BLM (0.66) | BLMMEN1GRIN2DLMNACYP3A4 | |
| Maleic Acid SCHEMBL21801700 | 0.76 | TSHR (0.70) | BLMMEN1GRIN2DLMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210023017-A1 | YEAST CELL WALL PARTICLE ENCAPSULATION OF BIODEGRADABLE PRO-PAYLOADS | UNIV MASSACHUSETTS (US) | 2021-01-28 | — | — | US | disclosed |
| EP-3765089-A1 | YEAST CELL WALL PARTICLE ENCAPSULATION OF BIODEGRADABLE PRO-PAYLOADS | University of Massachusetts (US) | 2021-01-20 | — | — | EP | disclosed |
| WO-2019178443-A1 | YEAST CELL WALL PARTICLE ENCAPSULATION OF BIODEGRADABLE PRO-PAYLOADS | UNIVERSITY OF MASSACHUSETTS (US) | 2019-09-19 | — | — | WO | disclosed |