Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.70 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.70 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.70 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL21801699 | 1.00 | BLM (0.70) | BLMLMNAMEN1GRIN2DCYP3A4 | |
| Cycloserine SCHEMBL5146943 | 0.86 | BLM (0.66) | BLMLMNAMEN1GRIN2DCYP3A4 | |
| Cycloserine SCHEMBL8681114 | 0.84 | BLM (1.00) | BLMLMNAMEN1GRIN2DCYP3A4 | |
| Cycloserine SCHEMBL18584681 | 0.84 | BLM (1.00) | BLMLMNAMEN1GRIN2DCYP3A4 | |
| Cycloserine SCHEMBL34323 | 0.84 | — | — | |
| Cycloserine SCHEMBL6571320 | 0.82 | — | — | |
| Cycloserine SCHEMBL10448776 | 0.82 | — | — | |
| Maleic Acid SCHEMBL21801700 | 0.81 | TSHR (0.70) | BLMLMNAMEN1GRIN2DCYP3A4 | |
| Maleic Acid SCHEMBL21801701 | 0.81 | TSHR (0.70) | BLMLMNAMEN1GRIN2DCYP3A4 | |
| Cycloserine SCHEMBL14697213 | 0.81 | BLM (0.76) | BLMLMNAMEN1GRIN2DCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220047561-A1 | SALTS OF CYCLOSERINE COMPOUNDS AND APPLICATIONS THEREOF | SYNEURX INTERNATIONAL (TAIWAN) CORP. (TW) | 2022-02-17 | — | — | US | disclosed |
| EP-3849547-A1 | SALTS OF CYCLOSERINE COMPOUNDS AND APPLICATIONS THEREOF | Syneurx International (Taiwan) Corp. (TW) | 2021-07-21 | — | — | EP | disclosed |
| CN-112714645-A | Salts of cycloserine compounds and uses thereof | 心悦生医股份有限公司 | 2021-04-27 | — | — | CN | disclosed |
| WO-2020052620-A1 | SALTS OF CYCLOSERINE COMPOUNDS AND APPLICATIONS THEREOF | SYNEURX INTERNATIONAL (TAIWAN) CORP. (CN) | 2020-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220047561-A1 | SALTS OF CYCLOSERINE COMPOUNDS AND APPLICATIONS THEREOF | TST, RIMKLA, PSPH | BLM 3438/4885LMNA 4460/4885MEN1 1374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.