Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 2/20 | 0.33 |
| ▸ | MC5R | P33032 | 1/20 | 0.33 |
| ▸ | MC3R | P41968 | 1/20 | 0.33 |
| ▸ | MC1R | Q01726 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 3/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | WNT1 | P04628 | 1/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.31 |
| ▸ | ITGAV | P06756 | 2/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.31 |
| ▸ | CCNK | O75909 | 2/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.31 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | CDK7 | P50613 | 2/20 | 0.31 |
| ▸ | CCNH | P51946 | 2/20 | 0.31 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL213594 | 1.00 | BDKRB1 (0.34) | BDKRB1GSK3BDYRK1ACTSKMC4R | |
| SCHEMBL213595 | 1.00 | BDKRB1 (0.34) | BDKRB1GSK3BDYRK1ACTSKMC4R | |
| SCHEMBL4354883 | 0.93 | CTSK (0.32) | CTSKMC4RMC5RMC3RMC1R | |
| SCHEMBL2728456 | 0.93 | CCKBR (0.33) | BDKRB1GSK3BDYRK1ACTSKMC4R | |
| SCHEMBL211617 | 0.92 | BDKRB1 (0.35) | BDKRB1GSK3BDYRK1ACTSKWNT1 | |
| SCHEMBL213082 | 0.92 | BDKRB1 (0.33) | BDKRB1GSK3BDYRK1ACTSKMC4R | |
| SCHEMBL212336 | 0.92 | SYK (0.33) | BDKRB1GSK3BDYRK1ACTSKITGB3 | |
| SCHEMBL212335 | 0.92 | SYK (0.33) | BDKRB1GSK3BDYRK1ACTSKITGB3 | |
| SCHEMBL212334 | 0.92 | SYK (0.33) | BDKRB1GSK3BDYRK1ACTSKITGB3 | |
| SCHEMBL2724797 | 0.91 | EED (0.32) | BDKRB1GSK3BDYRK1ACTSKBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |