Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.34 |
| ▸ | OGA | O60502 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11814787 | 0.83 | MAPT (0.44) | ALDH1A1MAPTLMNA | |
| SCHEMBL14507095 | 0.78 | ALDH1A1 (0.38) | ALDH1A1MAPTKDM4EGAA | |
| SCHEMBL497532 | 0.77 | MAPT (0.38) | ALDH1A1MAPTLMNA | |
| SCHEMBL5718185 | 0.77 | — | — | |
| SCHEMBL11815703 | 0.77 | MAPT (0.43) | ALDH1A1MAPTKDM4ECYP2D6CYP3A4 | |
| SCHEMBL23102046 | 0.76 | TP53 (0.31) | — | |
| SCHEMBL497686 | 0.74 | MAPT (0.37) | ALDH1A1MAPTKDM4EHRH3KCNH2 | |
| SCHEMBL23661070 | 0.74 | MAPT (0.37) | ALDH1A1MAPTKDM4EHRH3KCNH2 | |
| SCHEMBL22401471 | 0.73 | CHRNA7 (0.44) | ALDH1A1MAPTKDM4EHRH3CHRNA7 | |
| SCHEMBL18071053 | 0.72 | ALDH1A1 (0.36) | ALDH1A1MAPTKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3765447-B1 | TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2023-07-12 | — | — | EP | disclosed |
| WO-2019178510-A1 | TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-09-19 | — | — | WO | disclosed |