Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 7/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 6/20 | 0.34 |
| ▸ | BLM | P54132 | 2/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 4/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21362065 | 0.81 | BRD4 (0.38) | — | |
| SCHEMBL20157965 | 0.80 | NR1I3 (0.33) | MAPK14PRMT5WDR77MEN1KMT2A | |
| SCHEMBL20157758 | 0.75 | RAF1 (0.40) | — | |
| SCHEMBL21362034 | 0.75 | RAF1 (0.38) | PRMT5WDR77GAA | |
| SCHEMBL21351986 | 0.73 | BRD4 (0.36) | MAPK14MAPTGAATP53MEN1 | |
| SCHEMBL28859608 | 0.72 | MMP8 (0.39) | MAPK14CYP17A1 | |
| SCHEMBL21362394 | 0.72 | BRD4 (0.39) | MAPK14POLBMAPT | |
| SCHEMBL21362563 | 0.69 | BRD4 (0.53) | POLBRAB9AMAPTTDP1MEN1 | |
| SCHEMBL20157926 | 0.68 | BRD4 (0.37) | POLBMAPT | |
| SCHEMBL10361607 | 0.68 | CYP17A1 (0.61) | MAPK14CYP17A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3539960-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | Luoxin Pharmaceutical (Shanghai) Co., Ltd. (CN) | 2019-09-18 | — | — | EP | disclosed |