Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | STRADA | Q7RTN6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20158084 | 0.81 | HTT (0.54) | MAPTNPC1MAPK1HTTALDH1A1 | |
| SCHEMBL20157484 | 0.78 | ALDH1A1 (0.48) | MAPTNPC1MAPK1HTTALDH1A1 | |
| SCHEMBL20157547 | 0.75 | MAPT (0.50) | MAPTNPC1MAPK1HTTALDH1A1 | |
| SCHEMBL12121014 | 0.74 | IDO1 (0.42) | MAPTMAOBMAPK14ALDH1A1KDM5A | |
| SCHEMBL20157816 | 0.73 | MAPT (0.51) | MAPTNPC1MAPK1HTTALDH1A1 | |
| SCHEMBL11964298 | 0.73 | HTT (0.57) | MAPK1HTTMAOBKDM5AKDM4C | |
| Sulfamide SCHEMBL21352056 | 0.73 | ALDH1A1 (0.43) | MAPTNPC1MAPK1HTTALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL28443748 | 0.73 | IDO1 (0.41) | MAPTMAOBMAPK14ALDH1A1KDM5A | |
| SCHEMBL20157414 | 0.73 | NPC1 (0.58) | MAPTNPC1MAPK1HTTALDH1A1 | |
| SCHEMBL20157483 | 0.72 | ALDH1A1 (0.50) | MAPTNPC1MAPK1HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3539960-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | Luoxin Pharmaceutical (Shanghai) Co., Ltd. (CN) | 2019-09-18 | — | — | EP | disclosed |