Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pramiracetam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | CA3 | P07451 | 1/20 | 0.57 |
| ▸ | CA4 | P22748 | 1/20 | 0.57 |
| ▸ | CA6 | P23280 | 1/20 | 0.57 |
| ▸ | CA5A | P35218 | 1/20 | 0.57 |
| ▸ | CA7 | P43166 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.57 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.57 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pramiracetam SCHEMBL195465 | 0.87 | LMNA (0.48) | LMNATSHRADRA1DADRA1AADRA1B | |
| Pramiracetam SCHEMBL11556360 | 0.86 | LMNA (0.47) | LMNATSHRADRA1DADRA1AADRA1B | |
| Pramiracetam SCHEMBL121209 | 0.86 | LMNA (0.47) | LMNATSHRADRA1DADRA1AADRA1B | |
| Pramiracetam SCHEMBL1171471 | 0.85 | LMNA (0.46) | LMNATSHRADRA1DADRA1AADRA1B | |
| Pramiracetam SCHEMBL120423 | 0.84 | LMNA (0.46) | LMNATSHRADRA1DADRA1AADRA1B | |
| Pramiracetam SCHEMBL4431064 | 0.79 | LMNA (0.40) | LMNATSHRADRA1DADRA1AADRA1B | |
| Etiracetam SCHEMBL373194 | 0.76 | LMNA (1.00) | LMNACA12CA1CA2CA3 | |
| Levetiracetam SCHEMBL118843 | 0.76 | LMNA (1.00) | LMNACA12CA1CA2CA3 | |
| Levetiracetam SCHEMBL5072485 | 0.76 | LMNA (1.00) | LMNACA12CA1CA2CA3 | |
| Levitiracetam SCHEMBL61493 | 0.76 | LMNA (1.00) | LMNACA12CA1CA2CA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262495-B1 | PHARMACEUTICAL COMPOSITION COMPRISING RACETAM AND CARNITINE AND PROCESS FOR ITS PREPARATION | BIOLAB SANUS FARMACEUTICA LTDA (BR) | 2018-10-31 | — | — | EP | disclosed |
| US-20110052556-A1 | PHARMACEUTICAL COMPOSITION COMPRISING RACETAM AND CARNITINE AND PROCESS FOR ITS PREPARATION | Biolab Sanus Farmaceutical Ltda (BR) | 2011-03-03 | — | — | US | disclosed |
| EP-2262495-A2 | PHARMACEUTICAL COMPOSITION COMPRISING RACETAM AND CARNITINE AND PROCESS FOR ITS PREPARATION | Biolab Sanus Farmacéutica Ltda (BR) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009105853-A2 | PHARMACEUTICAL COMPOSITION | BIOLAB SANUS FARMACEUTICA LTDA. (BR) | 2009-09-03 | — | — | WO | disclosed |