SCHEMBL21365243

SCHEMBL21365243

C[Si](c1ccccc1)(c1ccccc1)c1cccc(-c2ccc(N(c3ccc(-c4ccccc4)cc3)c3ccc(-c4ccccc4)cc3)cc2)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.37
GAA P10253 2/20 0.37
MGLL Q99685 1/20 0.36
KDM4E B2RXH2 2/20 0.35
ALDH1A1 P00352 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
MAPT P10636 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
MAOA P21397 1/20 0.35
BACE1 P56817 1/20 0.35
ALOX5 P09917 1/20 0.34
NISCH Q9Y2I1 1/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
APP P05067 1/20 0.33
HSD17B1 P14061 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17118577 0.91 ALDH1A1 (0.39) L3MBTL1MGLLKDM4EALDH1A1CYP1A2
SCHEMBL2329501 0.89 ALDH1A1 (0.40) L3MBTL1KDM4EALDH1A1CYP1A2CYP3A4
SCHEMBL21365232 0.84 MGLL (0.37) L3MBTL1GAAMGLLKDM4EALDH1A1
SCHEMBL17118567 0.84 MGLL (0.37) L3MBTL1GAAMGLLKDM4EALDH1A1
SCHEMBL12886071 0.82 NISCH (0.38) L3MBTL1GAAMGLLKDM4EALDH1A1
SCHEMBL24203504 0.81 ESR1 (0.42) L3MBTL1GAAMGLLKDM4EALDH1A1
SCHEMBL24203501 0.81 ESR1 (0.42) L3MBTL1GAAMGLLKDM4EALDH1A1
SCHEMBL24203502 0.81 ESR1 (0.42) L3MBTL1GAAMGLLKDM4EALDH1A1
SCHEMBL13837492 0.80 MEN1 (0.48) L3MBTL1GAAMGLLKDM4EALDH1A1
SCHEMBL10135834 0.80 MEN1 (0.48) L3MBTL1GAAMGLLKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190288220-A1 ORGANIC LIGHT-EMITTING DEVICE SAMSUNG DISPLAY CO., LTD. (KR) 2019-09-19 US disclosed