Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.68 |
| ▸ | MAOB | P27338 | 3/20 | 0.59 |
| ▸ | PPARG | P37231 | 5/20 | 0.58 |
| ▸ | PPARA | Q07869 | 3/20 | 0.57 |
| ▸ | LAP3 | P28838 | 1/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.56 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | PPARD | Q03181 | 1/20 | 0.54 |
| ▸ | MME | P08473 | 1/20 | 0.54 |
| ▸ | ACE | P12821 | 1/20 | 0.54 |
| ▸ | CPA1 | P15085 | 1/20 | 0.54 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27977003 | 1.00 | LTA4H (0.68) | LTA4HMAOBPPARGPPARALAP3 | |
| SCHEMBL25901508 | 0.90 | LTA4H (0.65) | LTA4HMAOBPPARGPPARALAP3 | |
| SCHEMBL16998508 | 0.87 | NPC1 (0.64) | LTA4HFFAR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4665082 | 0.87 | FFAR1 (0.67) | LTA4HMAOBPPARGPPARALAP3 | |
| SCHEMBL10071090 | 0.87 | FFAR1 (0.67) | LTA4HMAOBPPARGPPARALAP3 | |
| SCHEMBL517463 | 0.86 | ALDH1A1 (0.60) | NPC1RAB9AL3MBTL1 | |
| SCHEMBL2600694 | 0.86 | ALDH1A1 (0.60) | NPC1RAB9AL3MBTL1 | |
| SCHEMBL17761604 | 0.86 | ALDH1A1 (0.60) | NPC1RAB9AL3MBTL1 | |
| SCHEMBL2164928 | 0.86 | LTA4H (0.72) | LTA4HMAOBPPARGPPARALAP3 | |
| SCHEMBL6732617 | 0.86 | LTA4H (0.72) | LTA4HMAOBPPARGPPARALAP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019178401-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2019-09-19 | — | — | WO | disclosed |