Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 10/20 | 0.54 |
| ▸ | F2 | P00734 | 3/20 | 0.54 |
| ▸ | CTSG | P08311 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PREP | P48147 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21358337 | 1.00 | ELANE (0.54) | ELANEF2CTSGNPC1RAB9A | |
| SCHEMBL21360115 | 1.00 | ELANE (0.54) | ELANEF2CTSGNPC1RAB9A | |
| SCHEMBL31367113 | 1.00 | ELANE (0.54) | ELANEF2CTSGNPC1RAB9A | |
| SCHEMBL30591216 | 0.87 | ELANE (0.52) | ELANEF2CTSGNPC1RAB9A | |
| SCHEMBL17428773 | 0.87 | ELANE (0.52) | ELANEF2CTSGNPC1RAB9A | |
| SCHEMBL30591356 | 0.86 | SMN1; SMN2 (0.49) | NPC1RAB9ASMN1; SMN2FKBP1ANPSR1 | |
| SCHEMBL30591394 | 0.86 | SMN1; SMN2 (0.49) | NPC1RAB9ASMN1; SMN2FKBP1ANPSR1 | |
| SCHEMBL30591324 | 0.85 | SMN1; SMN2 (0.48) | NPC1RAB9ASMN1; SMN2FKBP1ANPSR1 | |
| SCHEMBL8284648 | 0.85 | FKBP1A (0.48) | ELANENPC1RAB9ASMN1; SMN2FKBP1A | |
| SCHEMBL23270785 | 0.83 | SMN1; SMN2 (0.52) | NPC1RAB9ASMN1; SMN2FKBP1ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019177873-A1 | ARGINASE INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME CORP. (US) | 2019-09-19 | — | — | WO | disclosed |