Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PREP | P48147 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8281753 | 0.90 | ELANE (0.49) | NPC1RAB9ASMN1; SMN2SIGMAR1ELANE | |
| SCHEMBL8355480 | 0.90 | ELANE (0.49) | NPC1RAB9ASMN1; SMN2SIGMAR1ELANE | |
| SCHEMBL30591394 | 0.86 | SMN1; SMN2 (0.49) | FKBP1ANPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL30591356 | 0.86 | SMN1; SMN2 (0.49) | FKBP1ANPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL30591324 | 0.85 | SMN1; SMN2 (0.48) | FKBP1ANPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL21358337 | 0.85 | ELANE (0.54) | FKBP1ANPC1RAB9ASMN1; SMN2ELANE | |
| SCHEMBL21360115 | 0.85 | ELANE (0.54) | FKBP1ANPC1RAB9ASMN1; SMN2ELANE | |
| SCHEMBL21367036 | 0.85 | ELANE (0.54) | FKBP1ANPC1RAB9ASMN1; SMN2ELANE | |
| SCHEMBL31367113 | 0.85 | ELANE (0.54) | FKBP1ANPC1RAB9ASMN1; SMN2ELANE | |
| SCHEMBL23270785 | 0.83 | SMN1; SMN2 (0.52) | FKBP1ANPC1RAB9ASMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1939213-A1 | Novel compounds as inhibitors of hepatitis C virus NS3 serine protease | SCHERING CORPORATION (US) | 2008-07-02 | — | — | EP | disclosed |
| WO-2005087725-A2 | NOVEL COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE | SCHERING CORPORATION (US) | 2005-09-22 | — | — | WO | disclosed |
| WO-2005085275-A1 | INHIBITORS OF HEPATITIS C VIRUS NS3 PROTEASE | SCHERING CORPORATION (US) | 2005-09-15 | — | — | WO | disclosed |