Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4255524 | 0.82 | SLC22A12 (0.41) | SLC22A12FGFR1FGFR4NOTUMPDE4A | |
| SCHEMBL28194794 | 0.81 | SLC22A12 (0.42) | SLC22A12FGFR1FGFR4NOTUMPDE4A | |
| SCHEMBL4008337 | 0.80 | NOTUM (0.47) | SLC22A12FGFR1FGFR4NOTUMP2RX7 | |
| SCHEMBL21822975 | 0.79 | ADORA2A (0.41) | SLC22A12FGFR1FGFR4NOTUMPDE4A | |
| SCHEMBL4015921 | 0.79 | FGFR1 (0.40) | SLC22A12FGFR1FGFR4NOTUMPDE4A | |
| SCHEMBL19993789 | 0.79 | ADK (0.45) | PRMT5WDR77 | |
| SCHEMBL24753119 | 0.78 | FGFR1 (0.44) | SLC22A12FGFR1FGFR4NOTUMPDE4A | |
| SCHEMBL22942935 | 0.78 | FGFR1 (0.39) | SLC22A12FGFR1FGFR4NOTUMPDE4A | |
| SCHEMBL7664462 | 0.78 | FGFR1 (0.46) | SLC22A12FGFR1FGFR4NOTUMPDE4A | |
| SCHEMBL3541053 | 0.78 | NOTUM (0.58) | FGFR1FGFR4NOTUMKCNH2SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019178368-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2019-09-19 | — | — | WO | disclosed |