Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.47 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | RHEB | Q15382 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | BCL6 | P41182 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28194794 | 0.83 | SLC22A12 (0.42) | NOTUMSLC22A12FGFR1FGFR4P2RX7 | |
| SCHEMBL21137545 | 0.82 | NOTUM (0.43) | NOTUMSLC22A12FGFR1FGFR4P2RX7 | |
| SCHEMBL28112933 | 0.81 | NOTUM (0.43) | NOTUMSLC22A12FGFR1FGFR4PTGS2 | |
| SCHEMBL3257655 | 0.81 | CFD (0.45) | NOTUM | |
| SCHEMBL6703844 | 0.80 | MAPT (0.43) | NOTUMSLC22A12FGFR1FGFR4P2RX7 | |
| SCHEMBL21367167 | 0.80 | SLC22A12 (0.44) | NOTUMSLC22A12FGFR1FGFR4P2RX7 | |
| SCHEMBL4014331 | 0.79 | HDAC6 (0.41) | NOTUMSLC22A12FGFR1FGFR4P2RX7 | |
| SCHEMBL19208537 | 0.79 | NOTUM (0.42) | NOTUMKMT2APTGS2 | |
| SCHEMBL15600230 | 0.78 | HDAC1 (0.48) | P2RX7RHEBKMT2AHDAC6HDAC4 | |
| SCHEMBL29781672 | 0.78 | ENPP3 (0.49) | NOTUMFGFR1FGFR4RHEBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080682-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |