Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 3/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | AR | P10275 | 1/20 | 0.62 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.62 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.62 |
| ▸ | CYP19A1 | P11511 | 11/20 | 0.60 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23223025 | 1.00 | PGR (0.62) | PGRCYP3A4ALDH1A1CYP2C19AR | |
| SCHEMBL23638353 | 1.00 | PGR (0.62) | PGRCYP3A4ALDH1A1CYP2C19AR | |
| SCHEMBL19625856 | 1.00 | PGR (0.62) | PGRCYP3A4ALDH1A1CYP2C19AR | |
| SCHEMBL23514172 | 0.95 | PGR (0.59) | PGRCYP3A4ALDH1A1CYP2C19AR | |
| SCHEMBL23514272 | 0.95 | PGR (0.59) | PGRCYP3A4ALDH1A1CYP2C19AR | |
| SCHEMBL19625923 | 0.95 | PGR (0.59) | PGRCYP3A4ALDH1A1CYP2C19AR | |
| SCHEMBL29890691 | 0.95 | PGR (0.59) | PGRCYP3A4ALDH1A1CYP2C19AR | |
| SCHEMBL23514168 | 0.88 | PGR (0.64) | PGRCYP3A4ALDH1A1CYP2C19AR | |
| SCHEMBL21367233 | 0.88 | PGR (0.64) | PGRCYP3A4ALDH1A1CYP2C19AR | |
| SCHEMBL23638374 | 0.88 | PGR (0.64) | PGRCYP3A4ALDH1A1CYP2C19AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210179661-A1 | Intermediates for the Synthesis of Bile Acid Derivatives, in Particular of Obeticholic Acid | NZP UK Limited (GB) | 2021-06-17 | — | — | US | disclosed |
| US-10968250-B2 | Intermediates for the synthesis of bile acid derivatives, in particular of obeticholic acid | NZP UK Limited (GB) | 2021-04-06 | — | — | US | disclosed |
| US-20190284227-A1 | Intermediates for the Synthesis of Bile Acid Derivatives, in Particular of Obeticholic Acid | NZP UK Limited (GB) | 2019-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190284227-A1 | Intermediates for the Synthesis of Bile Acid Derivatives, in Particular of Obeticholic Acid | NR1H4, GPBAR1, SLC10A1 | PGR 941/4885CYP3A4 73/4885ALDH1A1 854/4885 |
| US-10968250-B2 | Intermediates for the synthesis of bile acid derivatives, in particular of obeticholic acid | NR1H4, GPBAR1, SLC10A1 | PGR 1492/4885CYP3A4 66/4885ALDH1A1 803/4885 |
| US-20210179661-A1 | Intermediates for the Synthesis of Bile Acid Derivatives, in Particular of Obeticholic Acid | NR1H4, GPBAR1, SLC10A1 | PGR 1492/4885CYP3A4 66/4885ALDH1A1 803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.