Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 18/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19920149 | 0.90 | GLS (0.56) | GLS | |
| SCHEMBL21368591 | 0.89 | GLS (0.59) | GLS | |
| SCHEMBL14987258 | 0.86 | GLS (0.70) | GLSALDH1A1HSD17B10 | |
| SCHEMBL16385031 | 0.84 | GLS (0.67) | GLSALDH1A1HSD17B10 | |
| SCHEMBL21484237 | 0.82 | GLS (0.68) | GLSALDH1A1HSD17B10 | |
| SCHEMBL14987278 | 0.79 | GLS (0.72) | GLSALDH1A1 | |
| SCHEMBL21368570 | 0.79 | GLS (0.54) | GLS | |
| SCHEMBL19920004 | 0.79 | GLS (0.62) | GLS | |
| SCHEMBL14987276 | 0.78 | GLS (0.78) | GLSALDH1A1HSD17B10 | |
| SCHEMBL14987105 | 0.77 | GLS (0.76) | GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3277276-B1 | METHODS OF ADMINISTERING GLUTAMINASE INHIBITORS | CALITHERA BIOSCIENCES INC (US) | 2020-11-04 | — | — | EP | disclosed |
| EP-2782570-B1 | HETEROCYCLIC INHIBITORS OF GLUTAMINASE | CALITHERA BIOSCIENCES INC (US) | 2019-09-18 | — | — | EP | disclosed |