Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 10/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14987102 | 0.86 | GLS (1.00) | GLSTSHRALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL21369002 | 0.79 | GLS (0.77) | GLSALDH1A1SMN1; SMN2RAB9APOLB | |
| SCHEMBL14987103 | 0.76 | GLS (1.00) | GLSTSHRALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL21368901 | 0.74 | GLS (0.77) | GLSALDH1A1 | |
| SCHEMBL19920004 | 0.73 | GLS (0.62) | GLS | |
| SCHEMBL19920149 | 0.73 | GLS (0.56) | GLS | |
| SCHEMBL22623433 | 0.69 | GLS (0.76) | GLS | |
| SCHEMBL14987619 | 0.69 | GLS (1.00) | GLSTSHRALDH1A1HSD17B10RAB9A | |
| SCHEMBL21369013 | 0.69 | ALDH1A1 (0.38) | GLSTSHRALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL14987286 | 0.69 | GLS (1.00) | GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782570-B1 | HETEROCYCLIC INHIBITORS OF GLUTAMINASE | CALITHERA BIOSCIENCES INC (US) | 2019-09-18 | — | — | EP | disclosed |