Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 12/20 | 0.78 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14987619 | 0.88 | GLS (1.00) | GLSGAAHSD17B10ALDH1A1HPGD | |
| SCHEMBL14987537 | 0.77 | GLS (0.86) | GLSGAAHSD17B10ALDH1A1HPGD | |
| SCHEMBL15727753 | 0.76 | GLS (0.76) | GLSGAAHSD17B10ALDH1A1HPGD | |
| SCHEMBL15727756 | 0.76 | GAA (0.73) | GLSGAAHSD17B10ALDH1A1HPGD | |
| SCHEMBL14987417 | 0.76 | GLS (0.76) | GLSGAAHSD17B10ALDH1A1HPGD | |
| SCHEMBL21443339 | 0.76 | GLS (0.60) | GLSHSD17B10ALDH1A1HPGD | |
| SCHEMBL14987542 | 0.74 | GLS (0.62) | GLSGAA | |
| SCHEMBL15727757 | 0.73 | GLS (0.67) | GLSGAAHSD17B10ALDH1A1HPGD | |
| SCHEMBL14987273 | 0.73 | GLS (1.00) | GLSHSD17B10MAPK1 | |
| SCHEMBL14986996 | 0.72 | GLS (0.90) | GLSALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782570-B1 | HETEROCYCLIC INHIBITORS OF GLUTAMINASE | CALITHERA BIOSCIENCES INC (US) | 2019-09-18 | — | — | EP | disclosed |