Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 3/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | PRNP | P04156 | 1/20 | 0.30 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1807301 | 0.78 | DRD2 (0.39) | MAOBRXRARXRBRXRGPRNP | |
| SCHEMBL1808153 | 0.78 | KDM4E (0.49) | HTTALDH1A1MALT1CYP3A4THRB | |
| SCHEMBL8180939 | 0.73 | MAOB (0.53) | MAOB | |
| SCHEMBL15717088 | 0.71 | MALT1 (0.41) | PGRMALT1 | |
| SCHEMBL24362396 | 0.71 | KDM4E (0.59) | MAOBHTTALDH1A1KDM4E | |
| SCHEMBL5648628 | 0.70 | PGR (0.49) | MAOBPGRHTTALDH1A1CYP3A4 | |
| SCHEMBL24357642 | 0.69 | KDM4E (0.50) | MAOBHTTALDH1A1KDM4E | |
| SCHEMBL24357847 | 0.69 | MAOB (0.44) | MAOBALDH1A1 | |
| SCHEMBL13613855 | 0.69 | PGR (0.37) | MAOBPGRRXRALMNAALDH1A1 | |
| SCHEMBL8648418 | 0.69 | HPGD (0.43) | PGRRXRARXRBRXRGLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2592071-B1 | Tricyclic heterocyclic compounds | BRISTOL MYERS SQUIBB CO (US) | 2019-09-18 | — | — | EP | disclosed |